Imperial College London (ICL) is a world-class university with a mission to benefit society through excellence in science, engineering, medicine and business. It leads on Work Package 5 (WP5) of the Innovative Medicines Initiative (IMI) DRAGON project. Within the DRAGON project, ICL's contribution is led by Dr. Guang Yang and Dr. Simon Walsh with the aim to: 1. promote the performance of general clinical related tasks (such as classification, detection, and segmentation); 2. improve the performance of clinical diagnosis, and identify novel acquisition methods, such as fast CT to facilitate the delivery of standardised quantitative image biomarkers; and 3. undertake a comparative assessment of the effectiveness of the different approaches for enhancing the reproducibility of extracted quantitative image biomarkers. This will help with the validation of privacy preserved and self adaptive imaging as well as will lead to a deep generative model to support multicentre, cross-border clinical data sharing.